| Pair Name | Oleanolic Acid, Apatinib | ||
| Phytochemical Name | Oleanolic Acid (PubChem CID: 10494 ) | ||
| Anticancer drug Name | Apatinib (PubChem CID: 11315474 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Drug Name | Apatinib |
| Adverse Reactions | Mouth and tongue sores, dizziness, itchy skin rashes all over the body, increased blood pressure. This was inferred hot nature anticancer drug. |
| Recommendations | Cold: Kochia scoparia; Patrina scabiosaefolia |
| Reference | Malignant tumors in the era of immunotherapy based on traditional Chinese medicine's "cold and hot theory" Construction of integrated traditional Chinese and Western medicine treatment paradigm[J]. Modern Journal of Integrated Traditional Chinese and Western Medicine,2023,32(12):1712-1716. DOI:10.3969/j.issn.1008-8849.2023.12.022. ref_link |
| Pair Name | Oleanolic Acid, Apatinib | |||
| Disease Info | [ICD-11: 2C12] | Hepatocellular carcinoma | Investigative | |
| Biological Phenomena | Induction-->Oxidative Stress | |||
| In Vitro Model | H22 | Hepatocellular carcinoma | Mus musculus (Mouse) | CVCL_H613 |
| In Vivo Model | H22 tumor-burdened mice model was established in vivo. | |||
| Result | OA can treat apatinib induced liver injury in H22 Tumor-burdened mice by enhancing the suppresssive effect of apatinib on the growth of tumor. | |||
| No. | Title | Href |
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| 1 | A Synergistic Combination of Oleanolic Acid and Apatinib to Enhance Antitumor Effect on Liver Cancer Cells and Protect against Hepatic Injury. Recent Pat Anticancer Drug Discov. 2024;19(2):199-208. doi: 10.2174/1574892818666230417093208. | Click |
